反应详情

Proceeding as in example 62, but replacing for 3-benzyloxy-4-methoxybenzaldehyde an equivalent quantity of 2-chloro-3-benzyloxy-4-methoxybenzaldehyde (obtained as described in example 84) and purifying the reaction raw product by chromatography on a silica gel column, eluting with methylene chloride/petroleum ether (b.p. 30°-70° C.)=1/1, 2-chloro-3-benzyloxy-4-hydroxybenzaldehyde was obtained, m.p. 149°-150° C. (from methylene chloride/petrolum ether, b.p. 30°-70° C.=1/2).

1. custompurifying
2. customthe reaction raw product by chromatography on a silica gel column
3. washeluting with methylene chloride/petroleum ether (b.p. 30°-70° C.)=1/1