HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 12837122, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Fluorobenzoyl chloride | HCID 67879 | — |
| Reactant | 2-Amino-6-fluorobenzoic acid | HCID 521142 | — |
| Catalyst | Benzyltrimethylammonium chloride | HCID 5963 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | HCID 12837122 | HCID 12837122 | 97.2% |
Reaction Steps
When 38.8 g of 6-fluoroanthranilic acid, 39 g of 4-fluorobenzoyl chloride, 20 g of 50% strength sodium hydroxide solution, 0.45 g of benzyltrimethylammonium chloride, 700 g of 1,2-dichloroethane and 32.7 g of thionyl chloride are used as starting materials, and the procedure described in Example 1 is employed, 62 g (96%) of 5-fluoro-2-(p-fluorophenyl)-4H-3,1-benzoxazin-4-one of melting point 189°-193° C. are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04673740 |
| Source dataset | uspto-grants-1987_06 |
| ORD ID | ord-5ffd8c38c1524ead8c3c2bf170e5223f |
| Source note | uspto-grants-1987_06 |