Ethanol → Ethyl 6-(2',5'-dimethylphenyl)-5-keto-3,3-dimethylhexanoate

HRID 65282Notes

Reaction equation

HRID 65282 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[CH2:9][C:10](=[O:19])[CH2:11][C:12]([CH3:18])([CH3:17])[CH2:13][C:14]([OH:16])=[O:15].S(=O)(=O)(O)O.[CH2:25](O)[CH3:26]>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[CH2:9][C:10](=[O:19])[CH2:11][C:12]([CH3:17])([CH3:18])[CH2:13][C:14]([O:16][CH2:25][CH3:26])=[O:15]

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 136881246-(2',5'-Dimethylphenyl)-5-keto-3,3-dimethyl hexanoic acid

Product 1

HCID 13688125Ethyl 6-(2',5'-dimethylphenyl)-5-keto-3,3-dimethylhexanoateYield 78%

Procedure

Utilizing the procedure of EXAMPLE XX 6-(2',5'-dimethylphenyl)-5-keto-3,3-dimethyl hexanoic acid was esterified with absolute ethanol in the presence of a catalytic amount of concentrated sulfuric acid to provide 15.52 g (78% yield) of ethyl 6-(2',5'-dimethylphenyl)-5-keto-3,3-dimethylhexanoate as a pale viscous oil.

Sources & evidence

ORD record
ord-d2b2694743c545219e9a3ff282fa39f1
Source dataset
uspto-grants-1986_09
Patent number
US04613617

Reaction notes

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