Benzoyl fluoride, 4-(trifluoromethyl)- → HCID 13690509, compound

HRID 652820Notes

Reaction equation

HRID 652820 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH2:11])[C:5](=[CH:9][CH:10]=1)[C:6]([OH:8])=[O:7].[F:12][C:13]([F:24])([F:23])[C:14]1[CH:22]=[CH:21][C:17]([C:18](F)=O)=[CH:16][CH:15]=1>>[F:1][C:2]1[CH:10]=[CH:9][C:5]2[C:6](=[O:8])[O:7][C:18]([C:17]3[CH:16]=[CH:15][C:14]([C:13]([F:12])([F:23])[F:24])=[CH:22][CH:21]=3)=[N:11][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 67784Benzoyl fluoride, 4-(trifluoromethyl)-HCID 27249674-Fluoroanthranilic acid

Product 1

HCID 13690509HCID 13690509, compoundYield 91.3%

Procedure

When the reaction conditions of Example 1 are employed but 11.6 g of 4-fluoroanthranilic acid and 14.4 g of p-trifluoromethylbenzoyl fluoride are used, 21.1 g (91%) of 7-fluoro-2-(p-trifluoromethylphenyl)-4H-3,1-benzoxazin-4-one of melting point 137°-139° C. are obtained.

Workup

  1. customWhen the reaction conditions of Example 1

Sources & evidence

ORD record
ord-677d57a9a3e14dd28385163945b553ea
Source dataset
uspto-grants-1987_06
Patent number
US04673740

Reaction notes

Loading…