Benzene → HCID 53638274, compound

Participants

Reaction Steps

A solution of 3.28 g (0.02 mole) of p-formylphenylacetic acid and 10.1 g (0.056 mole) of 1-morpholinocyclohexene in 40 ml of benzene was stirred at room temperature for 12 hours, after which 20 ml of 6N hydrochloric acid were added thereto. The mixture was then stirred at room temperature for a further 1 hour, after which it was extracted with diethyl ether. The extract was washed with water and dried over anhydrous sodium sulfate, and the solvent was removed to afford an oily substance, which was purified by silica gel chromatography, eluted with a 1:1 by volume mixture of hexane and ethyl acetate, to give 2.5 g (yield 51.2%) of the title compound as a colorless oily substance.

Provenance & Evidence