Pyridinium chloride → HCID 135589639, compound

HRID 652855Notes

Reaction equation

HRID 652855 reaction equation
[Cl:1][C:2]1[C:10]2[O:9][N:8]=[C:7]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:12]=3[F:18])[C:6]=2[CH:5]=[CH:4][C:3]=1[O:19]C.Cl.N1C=CC=CC=1>>[Cl:1][C:2]1[C:10]2[O:9][N:8]=[C:7]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:12]=3[F:18])[C:6]=2[CH:5]=[CH:4][C:3]=1[OH:19]

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 14012489HCID 14012489, compound

Product 1

HCID 135589639HCID 135589639, compound

Conditions

Temperature
200 °C

Procedure

A solid mixture of 7.1 g of 7-chloro-3-(2,4-difluorophenyl)-6-methoxy-1,2-benzisoxazole and 27.8 g of pyridine HCl is heated at 200° C. for one hour and the mixture poured into vigorously stirred ice water to precipitate a product. The product is filtered and dried giving 7-chloro-3-(2,4-difluorophenyl)-6-hydroxy-1,2-benzisoxazole which is recrystallized from toluene, mp 186°-190° C.

Workup

  1. customto precipitate a product
  2. filtrationThe product is filtered
  3. customdried

Sources & evidence

ORD record
ord-d859cad326b743eb9fb5ffab3c8e99c2
Source dataset
uspto-grants-1987_06
Patent number
US04673746

Reaction notes

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