Pyridinium chloride → 3-(2-Fluorophenyl)-6-hydroxy-7-methyl-1,2-benzisoxazole

HRID 652887Notes

Reaction equation

HRID 652887 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:12]2[CH:13]=[CH:14][C:15]([O:18]C)=[C:16]([CH3:17])[C:11]=2[O:10][N:9]=1.Cl.N1C=CC=CC=1>O>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:12]2[CH:13]=[CH:14][C:15]([OH:18])=[C:16]([CH3:17])[C:11]=2[O:10][N:9]=1

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 130157283-(2-Fluorophenyl)-6-methoxy-7-methyl-1,2-benzisoxazole

Product 1

HCID 1355896433-(2-Fluorophenyl)-6-hydroxy-7-methyl-1,2-benzisoxazole

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3-(2-fluorophenyl)-6-methoxy-7-methyl-1,2-benzisoxazole (16.1 g) is heated at 200° C. for two hours with 64 g of pyridine hydrochloride. The melt is poured into H2O and extracted with ethyl acetate. After washing with 5% HCl the ethyl acetate is dried and evaporated to give 3-(2-fluorophenyl)-6-hydroxy-7-methyl-1,2-benzisoxazole, mp 216°-219° C.

Workup

  1. extractionextracted with ethyl acetate
  2. washAfter washing with 5% HCl the ethyl acetate
  3. customis dried
  4. customevaporated

Sources & evidence

ORD record
ord-abbf792b4e344edf8e86d2fdb4002887
Source dataset
uspto-grants-1987_06
Patent number
US04673746

Reaction notes

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