HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 652895Generated: October 30, 2026
Nitrogen → 7-Chloro-3-(2,3-difluorophenyl)-6-methoxy-1,2-benzisoxazole
https://huagongshe.com/reaction/652895
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Nitrogen | HCID 947 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | [(E)-[(3-chloro-2-hydroxy-4-methoxyphenyl)-(2,3-difluorophenyl)methylidene]amino] acetate | HCID 136477386 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 7-Chloro-3-(2,3-difluorophenyl)-6-methoxy-1,2-benzisoxazole | HCID 14012498 | — |
Reaction Steps
To a mixture of 1.4 g of NaH in 200 ml of DMF, a solution of 19 g of E-3-chloro-2',3'-difluoro-2-hydroxy-4-methoxybenzophenone O-acetyl oxime in 200 ml of DMF is added dropwise in an atmosphere of N2. The mixture is stirred for one half hour and then warmed at 45° C. for one half hour. Water is added and a product precipitates and is filtered and dried giving 7-chloro-3-(2,3-difluorophenyl)-6-methoxy-1,2-benzisoxazole, mp 184°-189° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04673746 |
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| Source dataset | uspto-grants-1987_06 |
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| ORD ID | ord-673cb219219a4079ab3a664c6adb030a |
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| Source note | uspto-grants-1987_06 |
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