Pyridinium chloride → HCID 135589650, compound

HRID 652902Notes

Reaction equation

HRID 652902 reaction equation
[Cl:1][C:2]1[C:10]2[O:9][N:8]=[C:7]([C:11]3[CH:16]=[C:15]([F:17])[CH:14]=[CH:13][C:12]=3[F:18])[C:6]=2[CH:5]=[CH:4][C:3]=1[O:19]C.Cl.N1C=CC=CC=1>>[Cl:1][C:2]1[C:10]2[O:9][N:8]=[C:7]([C:11]3[CH:16]=[C:15]([F:17])[CH:14]=[CH:13][C:12]=3[F:18])[C:6]=2[CH:5]=[CH:4][C:3]=1[OH:19]

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 14012502HCID 14012502, compound

Product 1

HCID 135589650HCID 135589650, compound

Conditions

Temperature
200 °C

Procedure

A mixture of 10 g of 7-chloro-3-(2,5-difluorophenyl)-6-methoxy-1,2-benzisoxazole and 40 g of pyridine HCl is heated at 200° C. for 45 minutes. The hot mixture is poured into vigorously stirred ice water and a product precipitates out. The product is filtered and dried giving 7-chloro-3-(2,5-difluorophenyl)-6-hydroxy-1,2-benzisoxazole, mp 256°-257° C.

Workup

  1. customa product precipitates out
  2. filtrationThe product is filtered
  3. customdried

Sources & evidence

ORD record
ord-122352682aa54fb5ae4f11d1fa5cc275
Source dataset
uspto-grants-1987_06
Patent number
US04673746

Reaction notes

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