Pyridinium chloride → 2,3-Dichloro-2',4-dihydroxybenzophenone

HRID 652915Notes

Reaction equation

HRID 652915 reaction equation
[Cl:1][C:2]1[C:17]([Cl:18])=[C:16]([O:19]C)[CH:15]=[CH:14][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[O:12]C)=[O:5].Cl.N1C=CC=CC=1>>[Cl:1][C:2]1[C:17]([Cl:18])=[C:16]([OH:19])[CH:15]=[CH:14][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[OH:12])=[O:5]

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 140125702,3-Dichloro-2',4-dimethoxybenzophenone

Product 1

HCID 128540642,3-Dichloro-2',4-dihydroxybenzophenone

Conditions

Temperature
200 °C

Procedure

A solid mixture of 13 g of 2,3-dichloro-2',4-dimethoxybenzophenone and 52 g of pyridine HCl is heated at 200° C. for one hour. The hot mixture is then poured into vigorously stirred ice water. The product is extracted with ethyl acetate. The extract is dried over Na2SO4 and evaporated to give 2,3-dichloro-2',4-dihydroxybenzophenone, mp 197°-201° C.

Workup

  1. extractionThe product is extracted with ethyl acetate
  2. dry with materialThe extract is dried over Na2SO4
  3. customevaporated

Sources & evidence

ORD record
ord-71296e11e23844e49f6c1567f10f9b52
Source dataset
uspto-grants-1987_06
Patent number
US04673746

Reaction notes

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