HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 652950Generated: October 30, 2026
Potassium Carbonate → 3-(4-Chlorophenyl)-6-methoxy-1,2-benzisoxazole
https://huagongshe.com/reaction/652950
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | [(E)-[(4-chlorophenyl)-(2-hydroxy-4-methoxyphenyl)methylidene]amino] acetate | HCID 136477392 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 3-(4-Chlorophenyl)-6-methoxy-1,2-benzisoxazole | HCID 14012516 | — |
Reaction Steps
A mixture of 5.32 g of E-4'-chloro-2-hydroxy-4-methoxybenzophenone-O-acetyl oxime, 3.45 g of potassium carbonate and 50 ml of 2-butanone is heated under reflux at 80° C. for 2 hr. The reaction mixture is poured into water/ice. The precipitate is filtered, dried, and recrystallized from toluene/ether to give 3-(4-chlorophenyl)-6-methoxy-1,2-benzisoxazole, mp 148°-9° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04673746 |
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| Source dataset | uspto-grants-1987_06 |
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| ORD ID | ord-517ade6ddcbb4bd19dae1e003e97310a |
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| Source note | uspto-grants-1987_06 |
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