Pyridinium chloride → 3-(4-Chloro-phenyl)-benzo[D]isoxazol-6-OL

Participants

Reaction Conditions

Reaction Steps

A mixture of 60 g of pyridine hydrochloride and 12.0 g 3-(4-chlorophenyl)-6-methoxy-1,2-benzisoxazole is heated with stirring at 210° C. for 75 min. The hot reaction mixture is poured with vigorous stirring onto ice and the solid is filtered, dried, and recrystallized from toluene to afford 3-(4-chlorophenyl)-6-hydroxy-1,2-benzisoxazole, mp 203° C.

Provenance & Evidence