Water → HCID 54090577, compound

Participants

Reaction Steps

To a solution of 289 mg (0.438 mmol) of the amide compound prepared above in methanol (10 ml) was added 127 mg (0.668 mmol) of p-toluenesulfonic acid hydrate. The mixture was refluxed in an argon atmosphere for 7 hours. Water was added to the reaction mixture, and the mixture was adjusted with an aqueous solution of sodium carbonate to a pH of 9, followed by extraction with ethyl acetate. The organic layer was concentrated under reduced pressure, a the residue obtained was recrystallized from dichloromethane to give 101 mg (0.209 mmol) of N-benzhydryl-N'-[2-{5-(3,4-dihydroxyphenyl)-2,4-pentadienoyl}aminoethyl]piperazine. Spectrophotometric data of the product support the structure shown below. ##STR39##

Provenance & Evidence