反应详情

To a solution of 4.12 g (11.2 mmol) of the piperazine derivative in methanol (20 ml) and water (10 ml) was added 13.2 g (235 mmol) of of potassium hydroxide, and the mixture was refluxed for 19 hours. Water was added to the reaction mixture and the whole mixture was extracted with n-butanol. The organic layer was washed with water and concentrated by evaporation under reduced pressure. The residue was subjected to Sephadex column chromatography, eluted with methanol, to give 3.15 g (10.6 mmol) of N-(2-benzhydroxyethyl)piperazine.

1. temperaturethe mixture was refluxed for 19 hours
2. extractionthe whole mixture was extracted with n-butanol
3. washThe organic layer was washed with water
4. concentrationconcentrated by evaporation under reduced pressure
5. washeluted with methanol