反应详情

温度

50 °C

To a solution of 3.27 g of 2-chloroethanol in dry benzene (3.5 ml) was added 0.8 g of conc. sulfuric acid and the mixture was heated, under argon atmosphere, at 50° C. To the mixture was added slowly a solution of 5.0 g of benzhydrol in dry benzene (6.5 ml) and, after 30 minutes from the addition, the whole mixture was refluxed for 1.5 hours. After the mixture was allowed to cool, the benzene layer was washed with water and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, to give 6.7 g of benzhydryl 2-chloroethyl ether.

1. additionafter 30 minutes from the addition
2. temperaturethe whole mixture was refluxed for 1.5 hours
3. temperatureto cool
4. washthe benzene layer was washed with water
5. dry with materialdried over anhydrous sodium sulfate
6. customThe solvent was removed by distillation under reduced pressure