Sulfuric Acid → HCID 10563330, compound

HRID 652962Notes

Reaction equation

HRID 652962 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][OH:5].S(=O)(=O)(O)O.[CH:11](O)([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C1C=CC=CC=1>[Cl:1][CH2:2][CH2:3][CH2:4][O:5][CH:11]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 7037BenzhydrolHCID 123133-Chloro-1-propanol

Product 1

HCID 10563330HCID 10563330, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent3×

Procedure

To a solution of 3.85 g (40.7 mmol) of 3-chloro-1-propanol in benzene (4 ml) was added conc. sulfuric acid, followed by a solution of 5 g (27.2 mmol) of benzhydrol in benzene (6 ml), and the mixture was refluxed, under argon atmosphere, for 0.8 hours. The reaction mixture was diluted with benzene, washed with water and the organic layer was dried over magnesium sulfate. The solvent was distilled off under reduced pressure and there was obtained 6.80 g (26.1 mmol) of benzhydryl 3-chloropropyl ether.

Workup

  1. temperaturethe mixture was refluxed, under argon atmosphere, for 0.8 hours
  2. washwashed with water
  3. dry with materialthe organic layer was dried over magnesium sulfate
  4. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-70fd147989c14d9aa1991842394b8ad6
Source dataset
uspto-grants-1987_06
Patent number
US04673684

Reaction notes

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