4,7-Dichloroquinazoline → 4-[N-(7-chloro-4-quinazolinyl)-N-methylamino]phenol

HRID 653003Notes

Reaction equation

HRID 653003 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.S([O:17][C:18]1[CH:23]=[CH:22][C:21]([NH:24][CH3:25])=[CH:20][CH:19]=1)(O)(=O)=O>>[Cl:12][C:8]1[CH:7]=[C:6]2[C:11]([C:2]([N:24]([C:21]3[CH:22]=[CH:23][C:18]([OH:17])=[CH:19][CH:20]=3)[CH3:25])=[N:3][CH:4]=[N:5]2)=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 2418814,7-DichloroquinazolineHCID 10198132p-(N-methylamino)phenol sulfate

Product 1

HCID 135328844-[N-(7-chloro-4-quinazolinyl)-N-methylamino]phenol

Procedure

4,7-Dichloroquinazoline (prepared according to the method of Price et al, J. Am. Chem. Soc., 1946, 68, 1305) was reacted with 4-(N-methylamino)phenol sulfate, following essentially the same procedure as that described in Example 3 part a), to give 4-[N-(7-chloro-4-quinazolinyl)-N-methylamino]phenol as a yellow solid, mp 165° C.

Sources & evidence

ORD record
ord-512b51da061246baaddd16fc16a0c77f
Source dataset
uspto-grants-1987_06
Patent number
US04675047

Reaction notes

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