Ethyl 2-bromopropionate → HCID 13532894, compound

HRID 653004Notes

Reaction equation

HRID 653004 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]([C:14]3[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=3)[CH3:13])=[N:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.Br[CH:22]([CH3:28])[C:23]([O:25][CH2:26][CH3:27])=[O:24]>>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]([C:14]3[CH:19]=[CH:18][C:17]([O:20][CH:22]([CH3:28])[C:23]([O:25][CH2:26][CH3:27])=[O:24])=[CH:16][CH:15]=3)[CH3:13])=[N:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 79040Ethyl 2-bromopropionateHCID 135328844-[N-(7-chloro-4-quinazolinyl)-N-methylamino]phenol

Product 1

HCID 13532894HCID 13532894, compound

Procedure

4-[N-(7-Chloro-4-quinazolinyl)-N-methylamino]phenol was reacted with ethyl 2-bromopropionate, following essentially the same procedure as that described in Example 3 part(b), to give ethyl 2-{4-[N-(7-chloro-4-quinazolinyl)-N-methylamino]phenoxy}propionate as a yellow solid mp 92° C. The assigned structure was confirmed by proton magnetic resonance spectroscopy and mass spectrometry.

Sources & evidence

ORD record
ord-e0614afc656d447f967f78670fcde653
Source dataset
uspto-grants-1987_06
Patent number
US04675047

Reaction notes

Loading…