HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → benzyl N-(2-methyl-3-oxobutan-2-yl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Benzyl chloroformate | HCID 10387 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-Amino-3-methyl-2-butanone hydrochloride hydrate | HCID 21298602 | — |
| Solvent | Water | HCID 962 | — |
| Product | benzyl N-(2-methyl-3-oxobutan-2-yl)carbamate | HCID 21298536 | — |
Reaction Steps
3-Amino-3-methyl-2-butanone hydrochloride hydrate [J. Org. Chem. 49, 1209 (1984)] (10.6 g., 0.076 mol was dissolved in 700 ml. 1:1 THF:H2O and the pH adjusted to 6.8 with dilute NaOH. Benzylchloroformate (11.93 ml., 0.084 ml.) was added dropwise, maintaining pH 6.8-7.0 by the simultaneous dropwise addition of dilute NaOH. The pH was so maintained until it stabilized. The reaction mixture was extracted 4×100 ml. CHCl3. The organic extracts were combined, filtered and stripped to yield title product as an oil, 9.26.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04675186 |
| Source dataset | uspto-grants-1987_06 |
| ORD ID | ord-5748a1b7460940f189772b2cdce19b37 |
| Source note | uspto-grants-1987_06 |