反应详情

In 100 ml of benzene were dissolved 9.3 g of 4-ethoxycarbonylphenylhydrazine and 3.6 g of methyl isothiocyanate and then the solution was refluxed with stirring. After heat-refluxing for 5 hours, the reaction mixture thus formed was cooled and crystals thus formed were collected by filtration to provide 1-(4-ethoxycarbonylphenyl)-4-methylthiosemicarbazide as colorless crystals. The product, 1-(4-ethoxycarbonylphenyl)-4-methylthiosemicarbazide thus obtained could be used for the subsequent reaction without being purified.

1. temperaturethe solution was refluxed
2. temperatureAfter heat-refluxing for 5 hours
3. customthe reaction mixture thus formed
4. temperaturewas cooled
5. customcrystals thus formed
6. filtrationwere collected by filtration