Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Urea | HCID 1176 | — |
| Reactant | 3-Nitrobenzaldehyde | HCID 7449 | — |
| Reactant | Ethyl Acetoacetate | HCID 8868 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 20195530 | HCID 20195530 | — |
Reaction Steps
A mixture of urea (52 mmol), ethyl acetoacetate (78 mmol) and m-nitrobenzaldehyde (49 mmol) in absolute ethanol (30 mL) and concentrated hydrochloric acid (10 drop) was heated to reflux for 4.5 hours. Upon cooling to -20° C., a crude product crystallized. The crude product was recrystallized from isopropanol to afford the desired product as a white solid (m.p. 230.5°-233° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04675321 |
|---|
| Source dataset | uspto-grants-1987_06 |
|---|
| ORD ID | ord-9314c57a93be4e3aa4484e5bb1f7f424 |
|---|
| Source note | uspto-grants-1987_06 |
|---|
