反应详情

A mixture composed of 2-amino-6-trifluoromethoxybenzothiazole (2.34 g), 2,6-difluorobenzoylchloride (1.8 g) and chlorobenzene (20 ml) was boil for 1 hour. The hot reaction mixture was filtered and cooled to 10°-20° C. The resulting crystals were collected by filtration and washed with n-hexane (20 ml) to give N-(6-trifluoromethoxybenzothiazol-2-yl)-2,6-difluorobenzamide (3.15 g).

1. filtrationThe hot reaction mixture was filtered
2. temperaturecooled to 10°-20° C
3. filtrationThe resulting crystals were collected by filtration
4. washwashed with n-hexane (20 ml)