HCID 13458134, compound → HCID 13458137, compound

Participants

Reaction Steps

1-{2-Hydroxy-3-propyl-4-[2-(4-nitrophenoxy)ethoxy]phenyl}ethanone (6.0 g) was dissolved in a mixture of ethanol (250 ml) and dimethylformamide (60 ml) to which was added, under nitrogen, a slurry of palladium on charcoal (500 mg, 5%) in ethanol (50 ml). The suspension was then hydrogenated on a Parr at 60 psi and room temperature for 2 hours. The suspension was filtered over Celite, washed with ethanol and the filtrate evaporated under reduced pressure to give a brown oil. The oil was triturated with water and filtered to give a brown solid. The solid was recrystallised from ethanol to give a cream solid, m.p. 73°-74° C.

Provenance & Evidence