Potassium thiocyanate → HCID 13368598, compound

HRID 653077Notes

Reaction equation

HRID 653077 reaction equation
[OH:1][C:2]1[C:7]([CH2:8][CH2:9][CH3:10])=[C:6]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([CH2:19]Br)=[CH:15][CH:14]=2)[CH:5]=[CH:4][C:3]=1[C:21](=[O:23])[CH3:22].[S-:24][C:25]#[N:26].[K+]>CS(C)=O>[OH:1][C:2]1[C:7]([CH2:8][CH2:9][CH3:10])=[C:6]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([CH2:19][S:24][C:25]#[N:26])=[CH:15][CH:14]=2)[CH:5]=[CH:4][C:3]=1[C:21](=[O:23])[CH3:22]

Participants

4

Reactant 2

HCID 516872Potassium thiocyanateHCID 13019292HCID 13019292, compound

Product 1

HCID 13368598HCID 13368598, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

1-[2-Hydroxy-3-propyl-4-(4-bromomethylphenylmethoxy)phenyl]ethanone (6.4 g; 0.017 m) and potassium thiocyanate (3.3 g; 0.034 m) were dissolved in dry dimethylsulphoxide (60 ml) and stirred at room temperature for 4 hours. The solution was then poured onto water, stirred and filtered to give a white solid; dried at 60° C. under reduced pressure. Recrystallised from ethanol to give a white crystalline solid m.p. 110°-111° C.

Workup

  1. additionThe solution was then poured onto water
  2. stirringstirred
  3. filtrationfiltered
  4. customto give a white solid
  5. customdried at 60° C. under reduced pressure
  6. customRecrystallised from ethanol

Sources & evidence

ORD record
ord-3c96f3bf6e344a9da8171e3441b2966b
Source dataset
uspto-grants-1987_06
Patent number
US04675334

Reaction notes

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