4-Aminobenzophenone → HCID 20186543, compound

HRID 653115Notes

Reaction equation

HRID 653115 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:4][CH:3]=1.[Cl:16][CH2:17][CH2:18][C:19](Cl)=[O:20].[OH-].[Na+]>C(Cl)(Cl)Cl>[Cl:16][CH2:17][CH2:18][C:19]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[O:15])=[CH:6][CH:7]=1)=[O:20]

Participants

5

Reactant 3

HCID 143464-AminobenzophenoneHCID 14798Sodium HydroxideHCID 693643-Chloropropionyl chloride

Product 1

HCID 20186543HCID 20186543, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of 3.95 g of p-aminobenzophenone in 100 ml of chloroform was treated with 2.6 g of 3-chloropropionyl chloride and, after the addition of 26 ml of 1N sodium hydroxide solution, stirred at room temperature. The organic phase was separated, washed in sequence with water, 1N HCl and water, dried and evaporated. After recrystallization from methanol of the oil obtained there was obtained 4-(3-chloropropionamido)benzophenone, m.p. 135°-136° C.

Workup

  1. customThe organic phase was separated
  2. washwashed in sequence with water, 1N HCl and water
  3. customdried
  4. customevaporated
  5. customAfter recrystallization from methanol of the oil
  6. customobtained there

Sources & evidence

ORD record
ord-700c8ccf65cd4981b3bdcaec2054f39b
Source dataset
uspto-grants-1987_06
Patent number
US04675328

Reaction notes

Loading…