N-Phenylanthranilic Acid → 3-Hydroxy-1-(4-methoxyphenyl)-1H-indole-2-carboxylic acid methyl ester

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	N-Phenylanthranilic Acid	HCID 4386	—
Edukt	2-[(4-Methoxyphenyl)amino]benzoic acid	HCID 202918	—
Edukt	Methyl 3-hydroxy-1-phenyl-1H-indole-2-carboxylate	HCID 54687160	—
Produkt	3-Hydroxy-1-(4-methoxyphenyl)-1H-indole-2-carboxylic acid methyl ester	HCID 54738447	—

Reaktionsschritte

Prepared in a manner analogous to the multi-step procedure described [P. Friedlander and K. Kunz, Chem. Ber., 55, 1597 (1922)] for the preparation of 3-hydroxy-1-phenyl-1H-indole-2-carboxylic acid methyl ester, with 2-(4-methoxyphenylamino)benzoic acid substituted for 2-(phenylamino)benzoic acid in the first step of the synthetic sequence. The final indole product was recrystallized from 2-propanol to yield analytically pure product, mp 153°-155° C.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US04675332
Quelldatensatz	uspto-grants-1987_06
ORD ID	ord-7a870349fc1d4028a563d982566ba6a0
Quellennotiz	uspto-grants-1987_06