Potassium Hydroxide → HCID 13885795, compound

Participants

Reaction Steps

The crude 5-chloro-3-(1-methylethoxy)-1-phenyl-1H-indole-2-carboxylic acid methyl ester intermediate (14.8 g; 0.043 mole) was saponified with 6.4 g (0.11 mole) of potassium hydroxide as described in Example 1 to yield 10.2 g (72% yield) of the crude carboxylic acid product, mp 120° -dec. This material was used for further synthesis without additional purification.

Provenance & Evidence