Phosphorus pentachloride → 3-Methoxy-2,2,3,3-tetrafluoropropionyl chloride

HRID 653231Notes

Reaction equation

HRID 653231 reaction equation
[CH3:1][O:2][C:3]([F:11])([F:10])[C:4]([F:9])([F:8])[C:5](O)=[O:6].P(Cl)(Cl)(Cl)(Cl)[Cl:13]>>[CH3:1][O:2][C:3]([F:11])([F:10])[C:4]([F:9])([F:8])[C:5]([Cl:13])=[O:6]

Participants

3

Reactant 2

HCID 24819Phosphorus pentachlorideHCID 133289072,2,3,3-Tetrafluoro-3-methoxypropanoic acid

Product 1

HCID 128460263-Methoxy-2,2,3,3-tetrafluoropropionyl chlorideYield 95.2%

Procedure

A mixture of 47.4 g 3-methoxytetrafluoropropionic acid and 67.3 g phosphorous pentachloride was heated and the contents distilled to obtain a pale yellow liquid boiling to 102°. Redistillation of this liquid yielded 49.8 g (95.2%) 3-methoxytetrafluoropropionyl chloride, b.p. 84°-86°.

Workup

  1. temperaturewas heated
  2. distillationthe contents distilled
  3. customto obtain a pale yellow liquid boiling to 102°
  4. distillationRedistillation of this liquid

Sources & evidence

ORD record
ord-eeabb710280d4b77b2e9ff7c315946a0
Source dataset
uspto-grants-1987_06
Patent number
US04675453

Reaction notes

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