HCID 86740397, compound → HCID 86740414, compound

HRID 653267Notes

Reaction equation

HRID 653267 reaction equation
ClCC([NH:5][C:6]1[S:7][CH:8]=[C:9]([C:11](=[N:26][O:27][CH3:28])[C:12]([NH:14][C@H:15]2[C@@H:18]([S:19][CH3:20])[N:17]([S:21]([O-:24])(=[O:23])=[O:22])[C:16]2=[O:25])=[O:13])[N:10]=1)=O.[Na+:29].CSC(=S)N.[Na]>O>[NH2:5][C:6]1[S:7][CH:8]=[C:9]([C:11](=[N:26][O:27][CH3:28])[C:12]([NH:14][C@H:15]2[C@@H:18]([S:19][CH3:20])[N:17]([S:21]([O-:24])(=[O:23])=[O:22])[C:16]2=[O:25])=[O:13])[N:10]=1.[Na+:29]

Participants

4

Reactant 2

HCID 86740397HCID 86740397, compoundHCID 86740415HCID 86740415, compound

Product 1

HCID 86740414HCID 86740414, compoundYield 24.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 0.250 g of sodium (3R,4R)-3-[2-(2-chloroacetamidothiazol-4-yl)-2-methoxyiminoacetamido]-4-methylthio-2-oxoazetidine-1-sulfonate in 8 ml of water is added under ice-cooling 0.078 g of sodium monomethyldithiocarbamate, and the mixture is stirred at room temperature for 1.5 hours. The same procedure as Example 3B yields 0.052 g of sodium (3R,4R)-3-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-4-methylthio-2-oxoazetidine-1-sulfonate.

Sources & evidence

ORD record
ord-5b625a0ff75044efa0f8261397f2010c
Source dataset
uspto-grants-1987_06
Patent number
US04675397

Reaction notes

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