Potassium Hydroxide → HCID 21244492, compound

HRID 653300Notes

Reaction equation

HRID 653300 reaction equation
[OH-].[K+].C([O:5][C:6](=[O:18])[CH:7]([NH:13][C:14](=[O:17])[CH2:15][Cl:16])[C:8]1[N:9]=[CH:10][S:11][CH:12]=1)C>O.C(O)C>[Cl:16][CH2:15][C:14]([NH:13][CH:7]([C:8]1[N:9]=[CH:10][S:11][CH:12]=1)[C:6]([OH:18])=[O:5])=[O:17]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 57228633HCID 57228633, compound

Product 1

HCID 21244492HCID 21244492, compoundYield 84%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a solution of 2.5 g of potassium hydroxide in a mixture of 10 ml of water and 100 ml of ethanol is added 3.0 g of 2-chloroacetamido-4-thiazolyl acetic acid ethyl ester, and the mixture is stirred for one hour at room temperature. The solvent is evaporated under reduced pressure. To the residue is added 10 ml of water. The resulting aqueous solution is washed with ethyl acetate, and then adjusted to pH 2 with 10% hydrochloric acid, whereupon crystals separate out. The crystals are collected by filtration, washed with water, and dried to yield 2.2 g (84% ) of 2-chloroacetamido-4-thiazolyl acetic acid, m.p. 193°-195° C.

Workup

  1. customThe solvent is evaporated under reduced pressure
  2. additionTo the residue is added 10 ml of water
  3. washThe resulting aqueous solution is washed with ethyl acetate
  4. customseparate out
  5. filtrationThe crystals are collected by filtration
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-986b3b4b58014342b4ce59f60939854b
Source dataset
uspto-grants-1987_06
Patent number
US04675397

Reaction notes

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