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HRID653347

反应详情

EQUATION

反应方程式

HRID 653347 的结构方程式

REACTANTS

反应物

3
结构：[Na]
HCID5360545

Sodium

Na

结构：COC(=O)CCSCCO[C@@H]1O[C@H](COC(C)=O)[C@@H](O[C@H]2O[C@H](COC(C)=O)[C@@H](O[C@H]3O[C@H](CO[C@H]4O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]4OC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O
HCID18608304

未命名化合物

结构：CO.ClC(Cl)Cl.O
HCID21866399

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)CCSCCO[C@@H]1O[C@H](CO)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O[C@H]3O[C@H](CO[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O
HCID54077541

未命名化合物

收率 84%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

2 次

PROCEDURE

实验过程

Compound 94 (3.0 g, 2.2 mmol) was dissolved in methanol (25 ml) and added to a solution of sodium (1 mg) in methanol (75 ml). The reaction mixture was monitored by TLC (chloroform:methanol:water 65:35:10, lower phase). After 9 h at room temperature and 30 min at 40°, the solvent was removed and the residue was chromatographed (SiO2, chloroform:methanol:water, 65:35:10, lower phase) to give 98 (1.50 g, 84%). [α]D25 +113° (c 0.7, water). 1H-NMR (D2O, TSP) δ 5.41 (d, 2H, J=3.5 Hz, H1' and H1"), 4.98 (d, 1H, J=3.6 Hz, H1"'), 4.53 (d, 1H, J=7.9 Hz, H1), 3.75 (s, 3H, MeO). 13C-NMR (D2O, TSP) δ 177.4 (CO), 104.3 (Cl), 102.0, 101.6, 100.2 (Cl', Cl", Cl"'), 79.3, 79.1, 78.3, 76.7, 75.4, 75.2, 75.1, 73.9, 73.8, 73.6, 73.5, 73.3,,71.6, 71.5, 71.1, 68.0, 62.8, 62.7, 62.6, 62.6, 54.5, 36.3, 32.9, 28.6.

WORKUP

后处理

  1. custom30 min at 40°, the solvent was removed
  2. customthe residue was chromatographed (SiO2, chloroform:methanol:water, 65:35:10, lower phase)