HCID 54365226, compound → HCID 20194687, compound

HRID 653432Notes

Reaction equation

HRID 653432 reaction equation
C1(C[O:8][C:9](=[O:33])[CH2:10][CH2:11][C:12]2[CH:13]=[CH:14][CH:15]=[C:16]3[C:21]=2[N:20]([C:22](=[O:31])[C:23]2[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=2)[C:19](=[O:32])[CH2:18][CH2:17]3)C=CC=CC=1>[Pd]>[CH3:30][O:29][C:26]1[CH:25]=[CH:24][C:23]([C:22]([N:20]2[C:21]3[C:16](=[CH:15][CH:14]=[CH:13][C:12]=3[CH2:11][CH2:10][C:9]([OH:33])=[O:8])[CH2:17][CH2:18][C:19]2=[O:32])=[O:31])=[CH:28][CH:27]=1

Participants

3

Reactant 1

HCID 54365226HCID 54365226, compound

Product 1

HCID 20194687HCID 20194687, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumSolvent

Procedure

A solution of 1-(4-methoxybenzoyl)-1,2,3,4-tetrahydro-2-oxo-8-quinolinepropanoic acid phenylmethyl ester (10 g, 0.023 mole) is dissolved in tetrahydroferan (250 ml) and 1 g of 20% Pd/C is added. The mixture is shaken under an atmosphere of H2 gas until H2 absorption is complete. The mixture is filtered and concentrated at reduced pressure to yield after trituration with anhydrous diethylether and drying, 1-(4-methoxybenzoyl)-1,2,3,4-tetrahydro-2-oxo-8-quinolinepropanoic acid.

Workup

  1. additionis added
  2. filtrationThe mixture is filtered
  3. concentrationconcentrated at reduced pressure
  4. customto yield after trituration with anhydrous diethylether
  5. customdrying

Sources & evidence

ORD record
ord-4913c9cf546d4399b697ccca55b89c22
Source dataset
uspto-grants-1987_06
Patent number
US04677112

Reaction notes

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