Sodium Hydroxide → Cyclohexanamine, N-methyl-2-(1-pyrrolidinyl)-, trans-

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Reaction Steps

A mixture of 7-methyl-7-azabicyclo[4.1.0] heptane (7.0 g, 0.063 M), pyrrolidine (17.92 g, 0.25 M), water (10 ml) and ammonium chloride (0.16 g) was stirred and refluxed for 21 hours. The solution was cooled and solid sodium hydroxide added and extracted with ether (3×50 ml). The extracts were dried over magnesium sulphate and evaporated under reduced pressure to a brown oil. This was distilled under high vacuum to yield a colorless oil.

Provenance & Evidence