Potassium Hydroxide → HCID 20194734, compound

A mixture of ethyl 3-(3-furylthio)propionate (0.52 g, 0.0026 mole) and potassium hydroxide (0.29 g, 0.0052 m) in ethanol (25 ml) and water (1.0 ml) was stirred at ambient temperature for 4 hours. The mixture was concentrated in vacuo below 40° C., water (20 ml) was added to the residue and the solution extracted with methylene chloride (20 ml). The aqueous layer was acidified with 3NHCl, extracted with methylene chloride (3×25 ml) and the combined extracts washed twice with water. After drying over sodium sulfate, the solvent was evaporated in vacuo to give 0.15 g (33%) of oily product.

1. concentrationThe mixture was concentrated in vacuo below 40° C., water (20 ml)
2. additionwas added to the residue
3. extractionthe solution extracted with methylene chloride (20 ml)
4. extractionextracted with methylene chloride (3×25 ml)
5. washthe combined extracts washed twice with water
6. dry with materialAfter drying over sodium sulfate
7. customthe solvent was evaporated in vacuo

ORD record

ord-69efecd6690343b2b06ebf7a5fa21019

Source dataset

uspto-grants-1987_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04677115