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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 653467Generated: October 26, 2026

N-Acetylisoleucine → N-Acetyl-L-Ile-L-Tyr-(R)-1-Amino-2-(4-Hydroxyphenyl)ethylphosphonic Acid

https://huagongshe.com/reaction/653467

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-AcetylisoleucineHCID 7036275—
ReactantN-(O-benzyl-L-tyrosyl)-(R)-(-)-1-amino-2-(4-benzyloxyphenyl)ethylphosphonic acidHCID 18608402—
ProductN-Acetyl-L-Ile-L-Tyr-(R)-1-Amino-2-(4-Hydroxyphenyl)ethylphosphonic AcidHCID 18608377—

Reaction Steps

Diethyl ester of N-(N-acetyl-L-isoleucyl-L-tyrosyl)-(R)-(-)-1-amino-2-(4-hydroxyphenyl)ethylphosphonic acid was synthesized from N-acetyl-L-isoleucine and the compound 46a in the same condensation procedure as in Example 1 and then through the same reaction and treatment as in Example 8.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04677125
Source datasetuspto-grants-1987_06
ORD IDord-823b5f17fe5549c89d8c8c5c30bad4c3
Source noteuspto-grants-1987_06