Neopentylamine → HCID 20027823, compound

HRID 653477Notes

Reaction equation

HRID 653477 reaction equation
[CH2:1]([NH2:6])[C:2]([CH3:5])([CH3:4])[CH3:3].[N+:7]([C:10]1[CH:15]=[CH:14][C:13]([C:16]23[C:23](=O)[O:22][C:20](=[O:21])[CH:18]([CH2:19]2)[CH2:17]3)=[CH:12][CH:11]=1)([O-:9])=[O:8]>C(O)(=O)C>[CH2:1]([N:6]1[C:20](=[O:21])[CH:18]2[CH2:19][C:16]([C:13]3[CH:14]=[CH:15][C:10]([N+:7]([O-:9])=[O:8])=[CH:11][CH:12]=3)([CH2:17]2)[C:23]1=[O:22])[C:2]([CH3:5])([CH3:4])[CH3:3]

Participants

4

Reactant 2

HCID 79882NeopentylamineHCID 54107161HCID 54107161, compound

Product 1

HCID 20027823HCID 20027823, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

2.4 ml of neopentylamine are added dropwise at room temperature to a suspension of 2.5 g of 1-(4-nitrophenyl)-1,3-cyclobutanedicarboxylic acid anhydride in 6 ml of acetic acid. The mixture is stirred at 120° for 20 hours. After concentration by evaporation, the residue is chromatographed over silica gel with a 2:1 ether/hexane mixture. A fraction is obtained that is identical with the title compound of Example 4b.

Workup

  1. concentrationAfter concentration
  2. customby evaporation
  3. customthe residue is chromatographed over silica gel with a 2:1 ether/hexane mixture
  4. customA fraction is obtained

Sources & evidence

ORD record
ord-1c6533d093ec4940b024076ef7657074
Source dataset
uspto-grants-1987_06
Patent number
US04677129

Reaction notes

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