Hydrochloric Acid → HCID 20194902, compound

Participants

Reaction Conditions

Reaction Steps

Dimethyl 6-methoxytetrahydropyran-3,3-dicarboxylate (6.6 g, 0.028 mol) was added to a solution of sodium hydroxide (2.8 g, 0.07 mol) in water (10 ml), and the mixture was heated at 90° C. for 3 hours. After the reaction mixture was cooled to 0° C., 6N hydrochloric acid (12 ml, 0.07 mol) was added to neutralize the solution. After salting out, the mixture was extracted with five 30 ml portions of ethyl ether. The combined ether extracts were dried over anhydrous magnesium sulfate, filtered, and subjected to rotary evaporation. The residual white powder was recystallized from a mixture of diethyl ether and acetone (3:1). Yield of the product, which decomposed at 136° to 140° C., was 94%.

Provenance & Evidence