HCID 178450968, compound → HCID 178445988, compound

Participants

Reaction Steps

63 mg of Z-Phe-His-Leu-Val-7-tert.-butoxycarbonylheptyl amide (Example 28) are stirred for 10 minutes at room temperature in 1.5 ml of trifluoroacetic acid. The resulting solution is concentrated. The residue is purified by flash chromatography (30 g of silica gel 60, 40-63 μm, approximately 0.4 bar, eluant B1). The productcontaining fractions are combined and concentrated by evaporation. The residue is stirred in 2 ml of water, the solid portion is filtered off with suction and dried in a high vacuμmand the title compound is obtained in the form of a white powder. Rf (B11)=0.14.

Provenance & Evidence