HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → HCID 178445985, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | HCID 131714882 | HCID 131714882 | — |
| Reactant | Z-Phe-His-OH | HCID 178523857 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 178445985 | HCID 178445985 | — |
Reaction Steps
In a manner analogous to that described in Example 1, using as starting materials 50 mg of Z-Phe-His-OH, 28 mg of H-Leu-Val-methyl amide, 18 mg of HOBt and 31 mg of DCCI, the title compound is obtained after flash chromatography (35 g of silica gel 60, 40-63 μm, eluant system methylene chloride/methanol/concentrated ammonia 700:50:1). Rf (B2)=0.43, Rf (S10)=0.68.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04613676 |
| Source dataset | uspto-grants-1986_09 |
| ORD ID | ord-28c912e117a745d7a7c7a2e45217ce8d |
| Source note | uspto-grants-1986_09 |