N,N-Dimethylaniline → HCID 141560563, compound

Participants

Reaction Steps

1.82 g (2.62 mmol) of [(Z)-2-(1-benzhydryloxycarbonyl-1-cyclobutoxyimino)-2-(2-tritylaminothiazol-4-yl)acetic acid and 1.09 g (2.62 mmol) of benzhydryl 7-amino-3-chloromethyl-3-cephem-4-carboxylate were dissolved in 40 ml of methylene chloride, and then 1.06 ml (8.39 mmol) of N,N-dimethylaniline and 0.26 ml (2.75 mmol) of phosphorus oxychloride were dropwise added thereto under cooling with ice. The mixture was stirred at the same temperature for 4 hours. To the reaction solution, 30 ml of chloroform and 30 ml of water were added. The organic layer was washed with water and with a saturated sodium chloride aqueous solution, then dried over anhydrous sodium sulfate and concentrated to obtain a residue of the above-identified compound. The residue of the compound thus obtained was employed for the next reaction without purification.

Provenance & Evidence