HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → Z-Phe-His-Leu-Val Dimethyl amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | HCID 131714887 | HCID 131714887 | — |
| Reactant | Z-Phe-His-OH | HCID 178523857 | — |
| Product | Z-Phe-His-Leu-Val Dimethyl amide | HCID 178445984 | — |
Reaction Steps
In a manner analogous to that described in Example 1, using as starting materials 162 mg of Z-Phe-His-OH, 95 mg of H-Leu-Val-dimethyl amide, 57 mg of HOBt and 99 mg of DCCI, the title compound is obtained after flash chromatography (100 g of silica gel 60, 40-63 μm, system B3). Rf (B2)=0.57, Rf (S10)=0.74.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04613676 |
| Source dataset | uspto-grants-1986_09 |
| ORD ID | ord-fb848ec92383479eb5b15a3936b57fd0 |
| Source note | uspto-grants-1986_09 |