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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 653590Generated: October 30, 2026

3-Chloro-4-hydroxybenzoic acid → (R)-3-chloro-4-(2-n-hexyloxypropanoyloxy)benzoic acid

https://huagongshe.com/reaction/653590

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Chloro-4-hydroxybenzoic acidHCID 19860—
Reactant(R)-2-n-hexyloxypropanoyl chlorideHCID 22844813—
Product(R)-3-chloro-4-(2-n-hexyloxypropanoyloxy)benzoic acidHCID 22844815—

Reaction Steps

Using 3-chloro-4-hydroxybenzoic acid 1/2 hydrate (3.76 g, 20.7 mmol) and (R)-2-n-hexyloxypropanoyl chloride (3.98 g, 20.7 mmol), the reaction was carried out in the same manner as described in Example 4, (1), to give the title compound as a pale yellow oil; yield: 2.60 g.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05128062
Source datasetuspto-grants-1992_07
ORD IDord-4044d592bc5244ebbebd20288d3639ca
Source noteuspto-grants-1992_07