HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → Z-Phe-His-Leu-Val 3-(m-carbamoylphenoxy)-2-hydroxypropyl amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | HCID 131714889 | HCID 131714889 | — |
| Reactant | Z-Phe-His-OH | HCID 178523857 | — |
| Product | Z-Phe-His-Leu-Val 3-(m-carbamoylphenoxy)-2-hydroxypropyl amide | HCID 178445993 | — |
Reaction Steps
In a manner analogous to that described in Example 1, using as starting materials 77 mg of Z-Phe-His-OH, 37 mg of H-Leu-Val-3-(m-carbamoylphenoxy)- 2-hydroxypropyl amide, 27 mg of HOBt and 36 mg of DCCI, the title compound is obtained after flash chromatography (65 g of silica gel 60, 40-63 μm, eluant system B7). Rf (B7)=0.15, Rf (N12)=0.30.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04613676 |
| Source dataset | uspto-grants-1986_09 |
| ORD ID | ord-8b69f0843db34615a3ce494cbb020f11 |
| Source note | uspto-grants-1986_09 |