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HRID653634

反应详情

EQUATION

反应方程式

HRID 653634 的结构方程式

REACTANTS

反应物

2
反应SMILES：[CH3][Sn]([CH3])([CH3])[N]=[N+]=[N-]
HCID5104973

Azidotrimethyltin(IV)

C3H9N3Sn

反应SMILES：CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccncc2C#N)cc1
HCID19889390

7-Methyl-2-propyl-3-[[4-(3-cyanopyridin-4-yl)phenyl]methyl]imidazo[4,5-b]pyridine

C23H21N5

PRODUCTS

产物

1
反应SMILES：CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccncc2-c2nnn[nH]2)cc1
HCID178439911

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
反应SMILES：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

A solution of 7-methyl-2-propyl-3-[[4-(3-cyanopyridin-4-yl)phenyl]methyl]imidazo[4,5-b]pyridine (50 mg, 0.136 mmol) and trimethylstannylazide (84 mg, 0.408 mmol) in toluene (4 mL) was heated to reflux for 4 days. The mixture was cooled to rt, concentrated, then purified by flash chromatography on SiO2 (80/20/1 CH2Cl2 /MeOH/NH4OH) to give the product as a white solid.

WORKUP

后处理

  1. temperatureto reflux for 4 days
  2. concentrationconcentrated
  3. custompurified by flash chromatography on SiO2 (80/20/1 CH2Cl2 /MeOH/NH4OH)