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HRID653648

反应详情

EQUATION

反应方程式

HRID 653648 的结构方程式

REACTANTS

反应物

2
结构：[CH3][Sn]([CH3])([CH3])[N]=[N+]=[N-]
HCID5104973

Azidotrimethyltin(IV)

C3H9N3Sn

结构：CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2cccnc2C#N)cc1
HCID19889378

未命名化合物

PRODUCTS

生成物

1
结构：CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2cccnc2-c2nnn[nH]2)cc1
HCID178439910

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

A solution of 7-methyl-2-propyl-3-[[4-(2-cyanopyridin-3-yl)phenyl]methyl]imidazo[4,5-b]pyridine (300 mg, 0.817 mmol) and trimethylstannylazide (504mg, 2.45 mmol) in toluene (3 mL) was heated to reflux for 36 h. The mixture was cooled to rt, concentrated, then purified by flash chromatography on SiO2 (80/20/1 CH2Cl2 /MeOH/NH4OH) to give 7-methyl-2-propyl-3-[[4-[2-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]imidazo [4,5-b]pyridine as a white solid.

WORKUP

后处理

  1. temperatureto reflux for 36 h
  2. concentrationconcentrated
  3. custompurified by flash chromatography on SiO2 (80/20/1 CH2Cl2 /MeOH/NH4OH)