HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(4-Hydroxyphenyl)-2-[2-(isochroman-1-yl)-1-methylethylamino]-1-propanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-(2-Amino-1-hydroxypropyl)phenol | HCID 11099 | — |
| Reactant | 1-(Isochroman-1-yl)propan-2-one | HCID 12777063 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(4-Hydroxyphenyl)-2-[2-(isochroman-1-yl)-1-methylethylamino]-1-propanol | HCID 19889960 | 72% |
Reaction Steps
An oily product was obtained in the same manner as in Example 1, using (isochroman-1-yl)acetone and 2-amino-1-(4-hydroxyphenyl)-1-propanol [J. Med. Chem., 14, 148 (1971)]. The product was dissolved in anhydrous methanol, and concentrated hydrochloric acid was added thereto. The solvent was evaporated off to give a hydrochloride. The hydrochloride was then washed with ether to give Compound 24 as crystals in a yield of 72%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05128369 |
| Source dataset | uspto-grants-1992_07 |
| ORD ID | ord-309b8a8a7400410bb9a257c4a7f3f5cf |
| Source note | uspto-grants-1992_07 |