反应详情

In a mixture of 1N NaOH solution (4.5 ml) and methanol (10 ml), methyl 2-[4-(2-butylbenzimidazol-1-yl)methylphenyl]benzoate (1.2 g) was heated for 3 hours under reflux. The reaction mixture was concentrated, and the concentrate was dissolved in water, washed with ether, then acidified with 1N-HCl to afford crystals. The crystals were collected by filtration and recrystallized from ethyl acetate-methanol to afford colorless crystals (0.64 g, 53%).

1. temperaturewas heated for 3 hours
2. temperatureunder reflux
3. concentrationThe reaction mixture was concentrated
4. dissolutionthe concentrate was dissolved in water
5. washwashed with ether
6. customto afford crystals
7. filtrationThe crystals were collected by filtration
8. customrecrystallized from ethyl acetate-methanol