反应详情

A mixture of 2-amino-5-methyl benzoic acid (10 g) in methanol (50 ml) containing conc. sulfuric acid (5.5 ml) was heated for 19 hours under reflux. The solvent was distilled off, and the residue was dissolved in water. The solution was neutralized with an aqueous sodium hydroxide, followed by extraction with ethyl acetate. The organic layer was dried and concentrated to afford a pale brown oil (8.1 g, 74%).

1. temperaturewas heated for 19 hours
2. temperatureunder reflux
3. distillationThe solvent was distilled off
4. dissolutionthe residue was dissolved in water
5. extractionfollowed by extraction with ethyl acetate
6. customThe organic layer was dried
7. concentrationconcentrated