反应详情

A solution of 3-nitrophthalic acid (35 g) in ethanol (300 ml) containing conc. sulfuric acid (20 ml) was heated for 24 hours under reflux. The solvent was distilled off, and the residue was poured into ice-water (700 ml), which was extracted with ethyl acetate. The organic layer was washed with water, which was extracted with an aqueous solution of potassium carbonate. The aqueous layer was made acidic with hydrochloric acid, followed by extraction with methylene chloride. The organic layer was washed with water and dried. The solvent was distilled off to give a solid product (29 g, 74%), which was used in the subsequent reaction without purification.

1. temperaturewas heated for 24 hours
2. temperatureunder reflux
3. distillationThe solvent was distilled off
4. additionthe residue was poured into ice-water (700 ml), which
5. extractionwas extracted with ethyl acetate
6. washThe organic layer was washed with water, which
7. extractionwas extracted with an aqueous solution of potassium carbonate
8. extractionfollowed by extraction with methylene chloride
9. washThe organic layer was washed with water
10. customdried
11. distillationThe solvent was distilled off