Water → 6-Nitro-o-anisidine

Participants

Reaction Steps

A mixture of 2-amino-3-nitrophenol (7.7 g) and potassium carbonate (7.6 g) in DMF (15 ml) was stirred for 30 minutes at room temperature and there was then added methyl iodide (7.8 g). The mixture was stirred for 5 further hours at room temperature. To the reaction mixture was added water, which was extracted with ethyl acetate. The organic layer was washed with water and, then, dried. The solvent was distilled off to give crude crystals and recrystallization from isopropyl ether gave orange prisms (6.9 g, 82%), m.p. 76°-77° C.

Provenance & Evidence